Technology & Application

Lipid nanoprobe (LNP) extracellular vesicles (EVs) Isolation Technology

I. Isolation Principles

LNP leverages the fundamental structural characteristics of EVs, their outer bilayer lipid membrane, to isolate them.

II. LNP Enabled EVs-based omics-Diagnostic Workflow

Reference: Y. Wan, et al, Rapid magnetic isolation of extracellular vesicles via lipid-based nanoprobes, Nature Biomedical Engineering 1 (2017) 0058.

III. Key Features

Total EVs Isolation Efficiency

> 90% EVs capture

Downstream multi-omics Molecular Analysis

LNP captured EVs harboring high quality of nucleic acids (DNA and RNA), and unique proteins

Rapid Isolation

Simple workflow: one step in less than 15 mins

IV: Diagnostic Applications example

DNA point mutation (KRAS, EGFR) and gene fusion (ALK-ELM4 were successfully detected in LNP-isolated EVs in plasma of NSCLC patients.